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In the trial, patients with CLDN18.2 positive, metastatic, refractory or recurrent advanced GEC (NCT01197885) received 600 mg/m2 IMAB362 as a monotherapy every 2 weeks for 5 cycles. Final analyses indicate that partial response Michael Kors Clutch Uk

is a biopharmaceutical company with the mission of revolutionizing cancer treatment by developing a new class of therapeutic drugs called Ideal Monoclonal Antibodies (IMABs). IMABs are unique in that they are highly selective Michael Kors Handbags Over Shoulder

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Ganymed's lead program, IMAB362, is in advanced Phase II testing for gastroesophageal cancer. IMAB362 binds to the tight junction protein Claudin 18.2 which is expressed in up to 80% of gastroesophageal adenocarcinomas, 60% of pancreatic tumors as well as in other various solid tumors.

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IMAB362 was safe and well tolerated during the study with nausea and vomiting being the most frequent drug related adverse event.

for proteins which are present on tumor cells, but do not bind to healthy Michael Kors Bags Patent Leather

The median Progression Free Survival (PFS) was 102 days (95% CI), ranging from 70 to 146 days. Patients with clinical benefits had a median PFS of 262 days as compared to a median PFS of 70 days for patients with disease progression. Nine patients continued treatment beyond 5 cycles due to clinical benefit and one patient has been benefiting from treatment for over 16 months.

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"This study establishes IMAB362's high potential as novel treatment for patients with advanced gastroesophageal cancers," commented Professor Martin Schuler, West German Cancer Center, Essen, who coordinated the study. "The clinical activity seen in this heavily pretreated study population is very promising for an antibody monotherapy."

Michael Kors Wallet Yellow

Michael Kors Wallet Yellow

and stabilization of disease was achieved following IMAB362 treatment. A per protocol set of 21 patients showed a Disease Control Rate of 48%: Of these patients, 19% underwent partial remission and 29% achieved stable disease state according to the Response Evaluation Criteria In Solid Tumors (RECIST).

Ganymed is also developing IMAB027, a monoclonal antibody targeting Claudin 6 which is absent in healthy adult organs, but is expressed in a wide range of solid cancers, including testicular, ovarian, uterine, and lung cancers. IMAB027 is presently in Phase I/II clinical development for ovarian cancer.

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"I find it exciting that even as single agent, IMAB362 brought therapeutic benefits to patients to whom we have no other therapeutic options to offer," said Professor Emeritus Christoph Huber, Co founder and Supervisory Board member of Ganymed. "We are looking forward to seeing the results of the ongoing randomized Phase IIb study that includes 210 patients with gastroesophageal cancer receiving IMAB362 as first line therapy in combination with chemotherapy. Based on preclinical data a synergistic effect of adding IMAB362 to best standard care is expected."IMAB362 is a first in class antibody that is selective and specific for the tight junction protein CLDN18.2. This unique target is present only on differentiated cells of the stomach mucosa and is absent from all other healthy tissues. CLDN18.2 is however expressed in up to 80% of gastrointestinal adenocarcinomas, 60% of pancreatic tumors as well as in subsets of lung, ovarian and bile duct cancers. This makes IMAB362 the first antibody that is cancer cell selective while having little or no effect on healthy cells, thus reducing the risk of side effects. The majority of cases are diagnosed at an advanced stage which drastically reduces the effectiveness of current therapies resulting in a five year survival rate of less than 25%. Major unmet medical needs include lack of safe and effective systemic first line therapy, poor control of metastatic tumors and a complete absence of second line treatment options. Consequently, the need for earlier diagnosis and more effective therapies is extremely high.

´╗┐GANYMED Pharmaceuticals AGs IMAB362 Shows Strong Evidence Of Single Agent Activity In Phase 2a Trial In Gastroesophageal Cancer

Mainz, , May 27, 2014 / B3C Michael Kors Wallet Yellow newswire / announced today that its Ideal Monoclonal Antibody IMAB362 demonstrated significant safety and therapeutic benefits in a Phase IIa trial in gastroesophageal cancer (GEC). The trial involved 54 patients who had exhausted all other therapeutic options.

Michael Kors Wallet Yellow

Michael Kors Wallet Yellow

Michael Kors Wallet Yellow

cells. This unmatched tumor cell specificity makes IMABs cancer cell selective allowing them to efficiently kill tumor cells without harming normal healthy tissues. They can thus be administered at optimal dose and have a broad therapeutic window with reduced risks of side effects.

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